ISSN: 1859 - 2872
Treatment of left ventricular thrombus by rivaroxaban: An echocardiographic case report
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Keywords
Left ventricular thrombus, vitamin K antagonists, rivaroxaban
Tóm tắt
Treatment of left ventricular thrombus is challenging work for the clinician. Current guidelines recommend vitamin K antagonists for thrombus resolution, however there is a growing evidence that rivaroxaban can be used in selected cases. In the paper, we report a 47 year-old-man with a large left ventricular thrombus (60x70mm) which was treated with 10 month 15mg rivaroxaban twice per day. The outcome was total resolution of left ventricular thrombus. During the treatment course, there was an episode of stroke which was completely recovered. The patient was followed up for further recurrence of LV thrombus after stopping rivaroxaban at 10-month.
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Các tài liệu tham khảo
1. Rehan A, Kanwar M, Rosman H, Ahmed S, Ali A, Gardin J et al (2006) Incidence of post myocardial infarction left ventricular thrombus formation in the era of primary percutaneous intervention and glycoprotein IIb/IIIa inhibitors. A prospective observational study. Cardiovasc Ultrasound 4: 1476-7120.
2. Gianstefani S, Douiri A, Delithanasis I, Rogers T, Sen A, Kalra S et al (2014) Incidence and predictors of early left ventricular thrombus after ST-elevation myocardial infarction in the contemporary era of primary percutaneous coronary intervention. Am J Cardiol 113: 1111-1116.
3. Vaitkus PT, Barnathan ES (1993) Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: A meta-analysis. J Am Coll Cardiol 22: 1004-1009.
4. McCarthy CP, Vaduganathan M, McCarthy KJ, Januzzi JL, Bhatt DL, McEvoy JW (2018) Left ventricular thrombus after acute myocardial infarction: screening, prevention, and treatment. JAMA Cardiology 3: 642-629.
5. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B et al (2016) 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO). Europace 27.
6. Makrides CA (2016) Resolution of left ventricular postinfarction thrombi in patients undergoing percutaneous coronary intervention using rivaroxaban in addition to dual antiplatelet therapy. BMJ Case Rep 26: 2016-217843.
7. Azizi A, Puricel S, Cook S, Brugger N (2016) Rivaroxaban dissolves postinfarction left ventricular thrombus. Cardiovasc Med 19: 25-27.
8. Smetana KS, Dunne J, Parrott K, Davis GA, Collier AC, Covell M et al (2017) Oral factor Xa inhibitors for the treatment of left ventricular thrombus: A case series. J Thromb Thrombolysis 44: 519-524.
9. Robinson AA, Trankle CR, Eubanks G, Schumann C, Thompson P, Wallace RL et al (2020) Off-label use of direct oral anticoagulants compared with warfarin for left ventricular thrombi. JAMA Cardiol 5: 685-692.
2. Gianstefani S, Douiri A, Delithanasis I, Rogers T, Sen A, Kalra S et al (2014) Incidence and predictors of early left ventricular thrombus after ST-elevation myocardial infarction in the contemporary era of primary percutaneous coronary intervention. Am J Cardiol 113: 1111-1116.
3. Vaitkus PT, Barnathan ES (1993) Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: A meta-analysis. J Am Coll Cardiol 22: 1004-1009.
4. McCarthy CP, Vaduganathan M, McCarthy KJ, Januzzi JL, Bhatt DL, McEvoy JW (2018) Left ventricular thrombus after acute myocardial infarction: screening, prevention, and treatment. JAMA Cardiology 3: 642-629.
5. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B et al (2016) 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO). Europace 27.
6. Makrides CA (2016) Resolution of left ventricular postinfarction thrombi in patients undergoing percutaneous coronary intervention using rivaroxaban in addition to dual antiplatelet therapy. BMJ Case Rep 26: 2016-217843.
7. Azizi A, Puricel S, Cook S, Brugger N (2016) Rivaroxaban dissolves postinfarction left ventricular thrombus. Cardiovasc Med 19: 25-27.
8. Smetana KS, Dunne J, Parrott K, Davis GA, Collier AC, Covell M et al (2017) Oral factor Xa inhibitors for the treatment of left ventricular thrombus: A case series. J Thromb Thrombolysis 44: 519-524.
9. Robinson AA, Trankle CR, Eubanks G, Schumann C, Thompson P, Wallace RL et al (2020) Off-label use of direct oral anticoagulants compared with warfarin for left ventricular thrombi. JAMA Cardiol 5: 685-692.
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ChienD. V. (2021). Treatment of left ventricular thrombus by rivaroxaban: An echocardiographic case report. Journal of 108 - Clinical Medicine and Phamarcy, 16(TA). https://doi.org/10.52389/ydls.v16iTA.1097