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Objective: To study the stiffness characteristics of benign and malignant thyroid nodules on elastography ultrasound and the evaluation of elastography ultrasound in the diagnosis of thyroid cancer. Subject and method: This study included 535 patients with 557 thyroid nodules confirmed by histopathology, from September 2019 to August 2020. All patients were evaluated by elastography ultrasound, using US machine (GE Logiq S8, US) and ROI Qualified Elastography, the class the score of stiffness according to the Rago T.‘s score (2007). Result: Of 557 thyroid nodules, 7 nodules with stiffness score 1 (1.3%), 78 nodules with stiffness of score 2 (14.0%), 197 nodules with stiffness of score 3 (35.4%), 170 nodules with stiffness of score 4 (40.3%), 105 nodules with stiffness of score 5 (18.8%). In the group’s low stiffness (score 1, 2), the rate of benign thyroid nodules was higher than that of malignant’s group with p<0.05. In contrast, in the group’s high stiffness (score 4, 5), the rate of malignant thyroid nodules was higher than benign’s group with p<0.05. In the group’s medium stiffness (score 3), the difference between groups of benign and malignant thyroid nodules was not statistically significant (p>0.05). Diagnosis of a malignant thyroid nodules by elastography ultrasound had a sensitivity of 57.4% and a specificity of 91.3%. Conclusion: The stiffness of the malignant thyroid nodules was higher than that of thyroid nodules by elastography ultrasound; The diagnostic value of the malignant thyroid nodules had a sensitivity of 57.3% and a specificity of 91.3%.
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